Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 173)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0357483	0.0998195	0.7238214
Weighted median	23	-0.0509470	0.0577825	0.3779376
Inverse variance weighted	23	-0.1008121	0.0390154	0.0097688
Simple mode	23	-0.1094795	0.0951559	0.2622789
Weighted mode	23	-0.0401560	0.0705492	0.5749920

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.25761	21	0.5686184
Inverse variance weighted	21.46673	22	0.4920761

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0083862	0.0056423	0.1520577

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008528	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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