Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 172)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0096009	0.1039035	0.9272546
Weighted median	23	-0.0141211	0.0563756	0.8022146
Inverse variance weighted	23	0.0004341	0.0396881	0.9912740
Simple mode	23	0.0024268	0.0921231	0.9792212
Weighted mode	23	-0.0211835	0.0627362	0.7388206

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.75303	21	0.3572863
Inverse variance weighted	22.76496	22	0.4151016

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0006162	0.0058731	0.9174302

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006898	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8