Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 171)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2617089	0.0998193	0.0159347
Weighted median	23	0.0708717	0.0547175	0.1952411
Inverse variance weighted	23	-0.0051603	0.0410169	0.8998833
Simple mode	23	0.0388961	0.0890289	0.6664473
Weighted mode	23	0.0794427	0.0567980	0.1758462

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.87866	21	0.7764297
Inverse variance weighted	24.31524	22	0.3309246

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0163884	0.0056423	0.0084763

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007373	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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