Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 170)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0084818	0.0998210	0.9330897
Weighted median	23	-0.0410020	0.0524490	0.4343614
Inverse variance weighted	23	-0.0379244	0.0390158	0.3310371
Simple mode	23	-0.0214588	0.0814106	0.7945507
Weighted mode	23	-0.0458795	0.0644913	0.4843080

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	10.50677	21	0.9715526
Inverse variance weighted	10.60946	22	0.9798863

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018081	0.0056424	0.7517978

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0003501	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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