Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 17)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0926935	0.1181941	0.4416516
Weighted median	23	-0.0024141	0.0645195	0.9701526
Inverse variance weighted	23	0.0187875	0.0462498	0.6845823
Simple mode	23	0.0058392	0.1163733	0.9604343
Weighted mode	23	-0.0514314	0.0814380	0.5341950

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.44330	21	0.103759
Inverse variance weighted	30.91553	22	0.097857

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0068461	0.0066809	0.3171556

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009438	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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