Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 168)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2328359	0.1000628	0.0300565
Weighted median	23	0.0157601	0.0602782	0.7937409
Inverse variance weighted	23	0.0396418	0.0454819	0.3834289
Simple mode	23	-0.0279628	0.1152768	0.8105846
Weighted mode	23	-0.0480250	0.0757421	0.5325799

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.10255	21	0.4526970
Inverse variance weighted	29.89745	22	0.1209783

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0167329	0.005656	0.0075008

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009372	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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