Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 167)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.2326519	0.0998191	0.0298148
Weighted median	23	0.0015567	0.0576514	0.9784588
Inverse variance weighted	23	-0.0046175	0.0422951	0.9130643
Simple mode	23	-0.2041535	0.1215173	0.1070966
Weighted mode	23	0.0882230	0.0730997	0.2402932

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.18536	21	0.5732504
Inverse variance weighted	25.85429	22	0.2579908

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0145707	0.0056423	0.0173711

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007839	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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