Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 166)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1368901	0.1039656	0.2021334
Weighted median	23	-0.0666134	0.0561703	0.2356540
Inverse variance weighted	23	-0.0517681	0.0404428	0.2005340
Simple mode	23	0.0112977	0.0956833	0.9070808
Weighted mode	23	-0.0381728	0.0651912	0.5641358

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.78037	21	0.3557993
Inverse variance weighted	23.63869	22	0.3664496

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0052273	0.0058766	0.3838048

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007696	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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