Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 165)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1382618	0.1023163	0.1909731
Weighted median	23	0.0421278	0.0555435	0.4481732
Inverse variance weighted	23	-0.0000484	0.0410294	0.9990584
Simple mode	23	0.0233047	0.0941693	0.8068340
Weighted mode	23	0.0564034	0.0597244	0.3552259

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.06356	21	0.3958548
Inverse variance weighted	24.32964	22	0.3301904

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0084936	0.0057834	0.156757

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007373	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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