Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 164)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0118042	0.1273994	0.9270558
Weighted median	23	-0.0677611	0.0587594	0.2488299
Inverse variance weighted	23	-0.0614641	0.0488573	0.2083800
Simple mode	23	-0.1636910	0.1081282	0.1442964
Weighted mode	23	-0.0940523	0.0798197	0.2512620

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.20772	21	0.0344261
Inverse variance weighted	34.49986	22	0.0436638

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030496	0.0072012	0.6762479

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011206	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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