Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 163)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0558978	0.0998197	0.5814129
Weighted median	23	-0.0566785	0.0572892	0.3224968
Inverse variance weighted	23	-0.0002766	0.0390154	0.9943439
Simple mode	23	0.0480451	0.0893712	0.5962561
Weighted mode	23	-0.0568502	0.0846374	0.5087729

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.74577	21	0.7263975
Inverse variance weighted	17.11957	22	0.7567280

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034497	0.0056423	0.5475007

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005188	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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