Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 162)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1586439	0.0998203	0.1269369
Weighted median	23	0.0634930	0.0521045	0.2230072
Inverse variance weighted	23	0.0433670	0.0390157	0.2663417
Simple mode	23	0.0854768	0.0826397	0.3122181
Weighted mode	23	0.0550699	0.0604032	0.3718062

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.21949	21	0.7571947
Inverse variance weighted	17.79364	22	0.7181510

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0070791	0.0056423	0.2233904

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005766	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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