Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 161)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0311520	0.0998203	0.7580566
Weighted median	23	-0.0183737	0.0577787	0.7504845
Inverse variance weighted	23	-0.0251457	0.0390156	0.5192481
Simple mode	23	0.0001947	0.0884711	0.9982638
Weighted mode	23	-0.0141916	0.0658451	0.8313391

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.83870	21	0.7786442
Inverse variance weighted	16.21415	22	0.8051173

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034572	0.0056423	0.5466318

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005039	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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