Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 160)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1554948	0.1147889	0.1899364
Weighted median	23	-0.0268153	0.0551584	0.6268607
Inverse variance weighted	23	-0.0153629	0.0456337	0.7363762
Simple mode	23	-0.0088207	0.1023134	0.9320774
Weighted mode	23	-0.0435941	0.0637203	0.5010255

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.77077	21	0.1467731
Inverse variance weighted	30.09694	22	0.1161272

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0086055	0.0064884	0.1989904

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009167	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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