Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 16)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0844192	0.1227010	0.4989779
Weighted median	23	-0.0738479	0.0568907	0.1942641
Inverse variance weighted	23	-0.0667591	0.0468830	0.1544603
Simple mode	23	-0.1404739	0.0938803	0.1487824
Weighted mode	23	-0.0967774	0.0585773	0.1127100

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.73055	21	0.0623297
Inverse variance weighted	31.76749	22	0.0814473

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0010845	0.0069356	0.8772378

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010513	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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