Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 159)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0657257	0.0998200	0.5174087
Weighted median	23	-0.0150730	0.0574754	0.7931282
Inverse variance weighted	23	-0.0091405	0.0390155	0.8147692
Simple mode	23	-0.0831188	0.1105338	0.4600354
Weighted mode	23	-0.0576583	0.0772071	0.4630910

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.33437	21	0.7505795
Inverse variance weighted	16.99832	22	0.7634547

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045975	0.0056423	0.4243144

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005168	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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