Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 158)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1325401	0.1139339	0.2577533
Weighted median	23	-0.0646636	0.0532065	0.2242397
Inverse variance weighted	23	-0.0678553	0.0439003	0.1221850
Simple mode	23	-0.0593827	0.1079953	0.5879522
Weighted mode	23	-0.0715726	0.0592465	0.2398550

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.35824	21	0.1593077
Inverse variance weighted	27.85388	22	0.1805744

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0039723	0.0064401	0.5439923

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009357	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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