Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 157)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0357143	0.1070540	0.7419817
Weighted median	23	0.0013165	0.0569017	0.9815417
Inverse variance weighted	23	-0.0063288	0.0410575	0.8774961
Simple mode	23	0.0165645	0.0920010	0.8587639
Weighted mode	23	-0.0040898	0.0691962	0.9534029

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.15390	21	0.2856616
Inverse variance weighted	24.36329	22	0.3284788

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0025819	0.0060512	0.6739627

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007391	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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