Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 156)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0089111	0.1031979	0.9320067
Weighted median	23	-0.0678094	0.0598376	0.2571195
Inverse variance weighted	23	-0.0561194	0.0398460	0.1590100
Simple mode	23	-0.1213380	0.0966695	0.2225816
Weighted mode	23	-0.0993494	0.0743425	0.1950853

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.44576	21	0.3742249
Inverse variance weighted	22.94672	22	0.4047433

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0039935	0.0058333	0.5010742

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007581	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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