Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 155)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1727028	0.1016899	0.1042155
Weighted median	23	-0.0421896	0.0579822	0.4668394
Inverse variance weighted	23	-0.0308473	0.0409012	0.4507350
Simple mode	23	-0.0990897	0.0984367	0.3250552
Weighted mode	23	-0.0675765	0.0730921	0.3652362

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.79448	21	0.4114352
Inverse variance weighted	24.17824	22	0.3379560

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0087114	0.005748	0.1445435

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007516	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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