Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 154)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1925796	0.1100881	0.0948370
Weighted median	23	0.0013320	0.0540709	0.9803467
Inverse variance weighted	23	0.0087839	0.0452133	0.8459589
Simple mode	23	0.0386769	0.0943744	0.6858980
Weighted mode	23	0.0323767	0.0606348	0.5987219

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.54330	21	0.2244003
Inverse variance weighted	29.54504	22	0.1299479

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.011287	0.0062227	0.084021

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008967	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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