Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 153)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1023049	0.0998198	0.3170740
Weighted median	23	0.0743060	0.0551210	0.1776413
Inverse variance weighted	23	0.0558543	0.0390157	0.1522632
Simple mode	23	0.0527590	0.0855121	0.5435829
Weighted mode	23	0.0634161	0.0601330	0.3030538

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.58301	21	0.4846488
Inverse variance weighted	20.83860	22	0.5307312

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028525	0.0056423	0.6184291

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006936	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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