Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 152)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1406334	0.0998208	0.1735123
Weighted median	23	-0.0356680	0.0569615	0.5311984
Inverse variance weighted	23	-0.0144376	0.0390156	0.7113475
Simple mode	23	-0.0855172	0.0852885	0.3269161
Weighted mode	23	-0.0460168	0.0664034	0.4955682

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.47229	21	0.6189515
Inverse variance weighted	20.35875	22	0.5606102

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0077496	0.0056423	0.1840894

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000621	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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