Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 151)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0871840	0.1266636	0.4987904
Weighted median	23	-0.0392665	0.0606042	0.5170383
Inverse variance weighted	23	-0.0293081	0.0486521	0.5469071
Simple mode	23	-0.2117274	0.1257253	0.1063095
Weighted mode	23	-0.0571972	0.0725481	0.4388744

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.81363	21	0.0379384
Inverse variance weighted	34.21042	22	0.0467563

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0035541	0.0071596	0.6247577

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010537	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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