Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 150)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0854576	0.0998201	0.4015970
Weighted median	23	0.0338451	0.0550289	0.5385273
Inverse variance weighted	23	0.0374452	0.0390156	0.3371814
Simple mode	23	0.1238421	0.1018578	0.2369342
Weighted mode	23	0.0170765	0.0739502	0.8195119

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	18.55003	21	0.6139808
Inverse variance weighted	20.33934	22	0.5618223

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0075475	0.0056423	0.1953171

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006442	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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