Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 15)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0026942	0.1072726	0.9802004
Weighted median	23	0.0336340	0.0580871	0.5625710
Inverse variance weighted	23	0.0449218	0.0411425	0.2748951
Simple mode	23	0.1265837	0.1014653	0.2253105
Weighted mode	23	0.0221422	0.0714028	0.7594014

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.25280	21	0.2809717
Inverse variance weighted	24.46403	22	0.3233846

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0025932	0.0060635	0.673246

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007815	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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