Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 149)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1920366	0.1152608	0.1105405
Weighted median	23	0.0765777	0.0593912	0.1972666
Inverse variance weighted	23	0.0734854	0.0453043	0.1047942
Simple mode	23	-0.0633463	0.1013702	0.5384639
Weighted mode	23	0.0339768	0.0762748	0.6603458

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	27.99943	21	0.1401674
Inverse variance weighted	29.66429	22	0.1268549

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0072803	0.0065151	0.2764292

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010064	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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