Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1485)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0662547	0.0998803	0.5143288
Weighted median	23	0.0149975	0.0607536	0.8050179
Inverse variance weighted	23	-0.0107949	0.0390154	0.7820241
Simple mode	23	-0.1604841	0.1179544	0.1874303
Weighted mode	23	0.0580121	0.0887884	0.5202857

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.02539	21	0.4573946
Inverse variance weighted	21.72863	22	0.4761827

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0047316	0.0056457	0.4114193

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006608	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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