Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1484)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1690961	0.1048792	0.1218262
Weighted median	23	0.0495940	0.0560268	0.3760576
Inverse variance weighted	23	0.0584877	0.0412831	0.1565567
Simple mode	23	0.0727328	0.0860673	0.4071692
Weighted mode	23	0.0515334	0.0606484	0.4046399

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.18234	21	0.3343340
Inverse variance weighted	24.63156	22	0.3150163

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0067924	0.0059283	0.2647794

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008145	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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