Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1483)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1509570	0.0998194	0.1453613
Weighted median	23	-0.0005364	0.0556093	0.9923037
Inverse variance weighted	23	0.0359474	0.0404944	0.3746954
Simple mode	23	0.0020644	0.1080662	0.9849312
Weighted mode	23	-0.0220779	0.0699507	0.7552646

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.56142	21	0.5491728
Inverse variance weighted	23.69960	22	0.3631706

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0114778	0.0056423	0.0547502

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007439	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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