Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1482)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0055757	0.1081350	0.9593647
Weighted median	23	-0.0768431	0.0587124	0.1906007
Inverse variance weighted	23	-0.0519705	0.0415068	0.2105351
Simple mode	23	-0.0307850	0.1048835	0.7718787
Weighted mode	23	-0.0825555	0.0749602	0.2826596

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.64467	21	0.2628817
Inverse variance weighted	24.89965	22	0.3018979

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0028491	0.0061123	0.645925

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008083	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8