Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1481)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1594545	0.0998198	0.1251105
Weighted median	23	0.0247580	0.0576193	0.6674266
Inverse variance weighted	23	0.0044856	0.0390155	0.9084695
Simple mode	23	0.0491620	0.1081216	0.6537859
Weighted mode	23	0.0183322	0.0732138	0.8046074

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.16195	21	0.8147388
Inverse variance weighted	18.34568	22	0.6853078

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0100676	0.0056423	0.0888318

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005563	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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