Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1480)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1059813	0.0998169	0.3004048
Weighted median	23	-0.0285928	0.0598269	0.6327041
Inverse variance weighted	23	-0.0446115	0.0390149	0.2528523
Simple mode	23	-0.0058887	0.1086289	0.9572580
Weighted mode	23	0.0164436	0.1046903	0.8766229

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.66855	21	0.4793390
Inverse variance weighted	21.11472	22	0.5136582

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0037688	0.0056422	0.5114337

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006794	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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