Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1479)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2179166	0.0998205	0.0405240
Weighted median	23	-0.0229762	0.0554857	0.6788071
Inverse variance weighted	23	-0.0084851	0.0395050	0.8299356
Simple mode	23	0.0884017	0.0994804	0.3838131
Weighted mode	23	-0.0317996	0.0637244	0.6227206

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.35960	21	0.6890911
Inverse variance weighted	22.55529	22	0.4271926

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0128612	0.0056423	0.0332013

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006849	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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