Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1478)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0612504	0.1103221	0.5846270
Weighted median	23	0.0804793	0.0581453	0.1663256
Inverse variance weighted	23	0.0181774	0.0423089	0.6674609
Simple mode	23	0.0711692	0.0953966	0.4635439
Weighted mode	23	0.0711692	0.0675078	0.3032153

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.65130	21	0.2200582
Inverse variance weighted	25.87107	22	0.2572589

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0026451	0.0062359	0.6757543

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007905	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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