Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1477)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0189715	0.0998213	0.8510916
Weighted median	23	-0.0456047	0.0542904	0.4009012
Inverse variance weighted	23	-0.0305880	0.0390158	0.4330460
Simple mode	23	-0.0448430	0.0967979	0.6477255
Weighted mode	23	-0.0399820	0.0673642	0.5588866

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.66192	21	0.8836785
Inverse variance weighted	13.95286	22	0.9031438

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030434	0.0056424	0.5952917

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004414	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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