Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1476)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0773455	0.0998209	0.4470698
Weighted median	23	0.0675092	0.0561248	0.2290380
Inverse variance weighted	23	0.0376731	0.0390158	0.3342511
Simple mode	23	0.0970949	0.0831373	0.2553543
Weighted mode	23	0.0562935	0.0673278	0.4120822

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	15.93688	21	0.7731873
Inverse variance weighted	16.12331	22	0.8097189

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0024363	0.0056424	0.6702991

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005168	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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