Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1475)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0573617	0.1118226	0.6133263
Weighted median	23	-0.0395211	0.0561590	0.4815972
Inverse variance weighted	23	-0.0117957	0.0429005	0.7833503
Simple mode	23	-0.1052486	0.0950716	0.2802321
Weighted mode	23	-0.0537142	0.0665623	0.4283185

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.35349	21	0.1932900
Inverse variance weighted	26.59943	22	0.2268366

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0027982	0.0063207	0.662509

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008088	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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