Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1474)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0432778	0.1020417	0.6757922
Weighted median	23	-0.0189601	0.0549732	0.7301709
Inverse variance weighted	23	-0.0084461	0.0392471	0.8296096
Simple mode	23	-0.0501152	0.0851524	0.5621677
Weighted mode	23	-0.0331558	0.0602170	0.5874524

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.94485	21	0.4026938
Inverse variance weighted	22.26177	22	0.4443604

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031764	0.0057679	0.5876529

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000676	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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