Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1473)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0710684	0.1111767	0.5295797
Weighted median	23	-0.0816184	0.0602564	0.1755712
Inverse variance weighted	23	-0.0351190	0.0425797	0.4094946
Simple mode	23	-0.0903870	0.1157595	0.4432311
Weighted mode	23	-0.0806516	0.0800395	0.3245788

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.05032	21	0.2045368
Inverse variance weighted	26.20341	22	0.2430512

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0022077	0.0062843	0.728864

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008186	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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