Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1472)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0133662	0.1056587	0.9005368
Weighted median	23	-0.0268154	0.0601529	0.6557512
Inverse variance weighted	23	-0.0278388	0.0403695	0.4904459
Simple mode	23	0.0112136	0.1165677	0.9242339
Weighted mode	23	-0.0152750	0.0788305	0.8481333

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.52885	21	0.3164420
Inverse variance weighted	23.55366	22	0.3710523

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008888	0.0059723	0.8831208

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007292	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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