Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1471)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0681336	0.0998206	0.5023450
Weighted median	23	-0.0433123	0.0559627	0.4389607
Inverse variance weighted	23	0.0034487	0.0390156	0.9295643
Simple mode	23	-0.0483467	0.0982780	0.6276360
Weighted mode	23	-0.0509964	0.0595747	0.4012215

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.31872	21	0.6916140
Inverse variance weighted	17.92570	22	0.7103846

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0043959	0.0056423	0.4446209

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005434	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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