Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1470)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0949390	0.0998207	0.3523753
Weighted median	23	-0.0210910	0.0552573	0.7026933
Inverse variance weighted	23	-0.0029399	0.0390156	0.9399350
Simple mode	23	-0.0003520	0.0974325	0.9971499
Weighted mode	23	-0.0331859	0.0649703	0.6145885

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	13.56072	21	0.8877188
Inverse variance weighted	14.56331	22	0.8802874

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0056496	0.0056423	0.3280832

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004415	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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