Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 147)

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0152983	0.1024350	0.8827052
Weighted median	23	0.0037962	0.0538298	0.9437782
Inverse variance weighted	23	0.0210908	0.0391207	0.5898024
Simple mode	23	-0.0177751	0.0880350	0.8418429
Weighted mode	23	0.0020582	0.0658448	0.9753454

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	22.11449	21	0.3929384
Inverse variance weighted	22.11846	22	0.4528373

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0003557	0.0057901	0.9515935

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006791	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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