Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1469)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1708645	0.1066169	0.1239584
Weighted median	23	-0.0569865	0.0559507	0.3084346
Inverse variance weighted	23	-0.0719330	0.0462689	0.1200238
Simple mode	23	-0.0973681	0.0931158	0.3070684
Weighted mode	23	-0.0385014	0.0646324	0.5574564

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.95730	21	0.2951319
Inverse variance weighted	30.94049	22	0.0973397

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0149101	0.0060265	0.0219717

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010405	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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