Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1468)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0205467	0.0998208	0.8389014
Weighted median	23	-0.0043659	0.0579141	0.9399074
Inverse variance weighted	23	0.0223431	0.0390158	0.5668697
Simple mode	23	0.0437636	0.1027414	0.6742762
Weighted mode	23	-0.0162609	0.0674263	0.8116608

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.76129	21	0.7254712
Inverse variance weighted	16.97919	22	0.7645095

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0026339	0.0056424	0.6454485

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005245	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8