Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1467)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0248549	0.0998199	0.8057817
Weighted median	23	-0.0951118	0.0561404	0.0902317
Inverse variance weighted	23	-0.0739880	0.0390153	0.0579094
Simple mode	23	-0.1574802	0.0980788	0.1226106
Weighted mode	23	-0.1376352	0.0757348	0.0828140

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	17.75432	21	0.6644939
Inverse variance weighted	18.04029	22	0.7035971

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0030173	0.0056423	0.5984355

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006556	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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