Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1466)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0265734	0.0998209	0.7926732
Weighted median	23	-0.0607312	0.0547699	0.2674987
Inverse variance weighted	23	-0.0697880	0.0390157	0.0736603
Simple mode	23	-0.0464409	0.0883465	0.6043775
Weighted mode	23	-0.0526627	0.0560158	0.3573551

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.29074	21	0.5664957
Inverse variance weighted	20.39066	22	0.5586176

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0059175	0.0056423	0.3062043

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007148	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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