Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1465)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0043077	0.1071070	0.9682989
Weighted median	23	-0.0142742	0.0546126	0.7938061
Inverse variance weighted	23	0.0357313	0.0410613	0.3841949
Simple mode	23	0.0356108	0.0947651	0.7106801
Weighted mode	23	0.0143846	0.0624987	0.8200956

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.17771	21	0.2845279
Inverse variance weighted	24.36761	22	0.3282593

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0024588	0.0060542	0.6887566

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007638	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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