Two sample MR report

Telomere_length against rfMRI connectivity (ICA100 edge 1464)

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0989958	0.1008504	0.3374666
Weighted median	23	0.0406340	0.0608926	0.5045769
Inverse variance weighted	23	0.0433058	0.0390154	0.2670129
Simple mode	23	-0.0006468	0.1131638	0.9954913
Weighted mode	23	0.0274781	0.0847026	0.7486946

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.43619	21	0.4325981
Inverse variance weighted	21.80357	22	0.4716641

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0034199	0.0057006	0.5549733

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006981	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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